BDBM50191624 (3S)-(+)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)propyl]amino}-8-fluorochromane-5-carboxamide::(3S)-3-{cyclobutyl[3-(5-fluoro-1H-indol-3-yl)propyl]amino}-8-fluorochromane-5-carboxamide::CHEMBL208774

SMILES NC(=O)c1ccc(F)c2OC[C@H](Cc12)N(CCCc1c[nH]c2ccc(F)cc12)C1CCC1

InChI Key InChIKey=PTXOOZZUDQZJHO-SFHVURJKSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50191624   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191624((3S)-(+)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]paroxetine from 5-HT transporter in Sprague-Dawley rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191624((3S)-(+)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter in Sprague-Dawley rat frontal cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191624((3S)-(+)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataIC50:  17.4nMAssay Description:Inhibition of 5-HT transporter-mediated [3H]5HT uptake in human Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50191624((3S)-(+)-3-{Cyclobutyl[3-(5-fluoro-1H-indol-3-yl)p...)
Affinity DataIC50:  17.4nMAssay Description:Inhibition of [3H]5-HT uptake at human 5-HT transporter expressed in Jar cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed